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pentobarbital will lessen the extent or impact of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to some reduce in fentanyl plasma concentrations, not enough efficacy or, possibly, advancement of a withdrawal syndrome in a pati